What is acute fatty liver of pregnancy (AFLP)?

Acute fatty liver of pregnancy is a rare, but serious, condition of pregnancy in which there is an excessive accumulation of fat in the liver or liver cells. Fat normally accumulates in the liver in the form of triglycerides and fatty acids, but excessive fat can cause liver damage. AFLP is quite rare, however, it is a serious condition that cannot be predicted or prevented.

What causes acute fatty liver of pregnancy?

The cause of AFLP is unknown. It is thought that hormones of pregnancy play a role in this condition, but there does not seem to be an increased risk for future pregnancies.

Why is acute fatty liver of pregnancy a concern?

Both mother and fetus are at extremely high risk if AFLP is not treated. Liver failure, hemorrhage, kidney failure, and severe infection can be life threatening for the mother and fetus. Fortunately, early diagnosis and treatment helps to improve outcomes.

What are the symptoms of acute fatty liver of pregnancy?

AFLP usually begins late in the third trimester of pregnancy. The following are the most common symptoms of AFLP. However, each woman may experience symptoms differently. Symptoms may include:

• nausea and vomiting
• abdominal pain, especially in the right upper side
• malaise (general discomfort)
• headache
• tiredness
• confusion
• jaundice (yellow coloring of skin, eyes, and mucous membranes)

The symptoms of acute fatty liver of pregnancy may resemble other medical conditions. Always consult your physician for a diagnosis.

How is acute fatty liver of pregnancy diagnosed?

In addition to a complete medical history and physical examination, diagnosis of AFLP is most accurate by liver biopsy (taking a sample of liver tissue for examination under a microscope), but this is not always possible in pregnancy. Usually, the symptoms of AFLP are often clear enough to diagnose the condition. Blood tests can rule out other conditions or diseases that have similar symptoms. Ultrasound (a diagnostic imaging technique which uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs) or computed tomography (CT) scan (a diagnostic imaging procedure that uses a combination of x-rays and computer technology to produce cross-sectional images, often called slices, both horizontally and vertically, of the body) may also be used for diagnosis.

Treatment for acute fatty liver of pregnancy:

Once the condition is diagnosed, the baby is delivered as quickly as possible to minimize the risks to mother and baby. The mother may require intensive care for several days after delivery until her condition improves. In most cases, liver function returns to normal within a few weeks.