ATLAS (Ambulatory Therapies for Leakage Associated with Stress) - This study will determine whether pelvic muscle training and exercises, pessary use, or a combination of both exercises and pessary is most effective at improving incontinence in women. The study's primary hypothesis is that pessary use is more effective than pelvic muscle exercises after 3 months of treatment.
Enhancing Conservative Therapy for Urge Incontinence - The primary objective of this project is to evaluate whether enhancing drug therapy with components of behavioral training, including pelvic floor muscle rehabilitation, results in better outcomes than drug therapy alone for urge incontinence in community-dwelling women.
PRIDE (Program to Reduce Incontinence by Diet and Exercise) - This will evaluate the impact of weight loss on urinary incontinence in a randomized, controlled trial.
RUBI (Refractory Urge Botox Injection) - The purpose of this study is to determine how effective Botox (Botulinum-A toxin) is in reducing the amount of urine leaked in those who have urinary urge incontinence that does not respond to medications and pelvic exercises.
TOMUS (Trial of Mid-Urethral Slings) - This clinical trial compares treatment success for two minimally invasive surgical procedures to treat stress urinary incontinence in women. These procedures are called mid-urethral slings. The secondary aims of the trial are to compare other outcomes for the two surgical procedures, including quality of life, sexual function, satisfaction with treatment outcomes, complications, and the need for other treatments(s) after surgery. Follow-up will be a minimum of two years.